Vampirella is the titular character of her respective series and the protagonist in Aliens-Vampirella, she is a vampire and along with some crewmates, investigate a cave below a base on mars on suspicion of vampire activity. The cave turns out to be filled with xenomorph Ovomorphs. The group's proximity trigger the eggs and the majority of them are attacked and subdued by Facehuggers including Vampirella, she awakens roughly 26 hours later to discover that the group has been sealed in the cave as part of a quarantine procedure. Vampirella as well as some members of the group start coughing and convulsing as they start to give birth to Chestbursters. Only Vampirella survives this process due to her nature as a vampire. After feeding to heal her chest wound, she and Lars try to find a way out whilst evading the Xenomorph threat. Vampirella later comes across the Xenomorph that hatched from her, a Vampire Queen variant.
Despite her status as a vampire, Vampirella is a moral person, being shocked and hurt at the implication that she would feed or hurt any of the group when one of them wonders what will happen if she goes hungry.