Smythe was a Seegson employee serving as Head of Synthetic Development aboard Sevastopol Station. When a lone Xenomorph was unleashed on the station by the crew of the Anesidora in 2137, he became one of the survivors desperately waiting for rescue.
Spedding and Smythe were in charge of trying to convince VIPs and clients into buying the Working Joe android model instead of the Weyland-Yutani. If they failed, the jobs Seegson had allocated them on Earth would be cancelled.
Symthe had supposedly messed up the android presentation during the tour with the final bidders, failing to receive any buyers. Spedding angrily fired Smythe, calling him a "jackass" in one of his audio logs. Smythe sent him an archive log stating that he was happy that he fired him since he hated working for him.
During the Xenomorph outbreak, Smythe and fellow survivor Russel took refuge outside the Synthetic Showroom where they hoarded supplies, with Russel announcing to any remaining survivors who came across his archive log that he would be setting up a shop.
Whilst Ripley was onboard the station, Russel and Smythe were exploring Seegson Synthetics around the fluid plant reception when a Working Joe began chasing Russel. In a fit of desperation, Russel ran to the elevator and was able to escape, abandoning Smythe. Afterwards, he shut down access to the elevator so the Joe couldn't follow him, but he sent a message to Smythe assuring that he will come back for him, to which Smythe angrily replied to.
Smythe's corpse can be found in Seegson Synthetics. A rolled up magazine was shoved down his throat which he choked to death on, presumably done by the Working Joe that was previously chasing Russel.
- The rolled up magazine forced down Smythe's throat is a direct homage to the original movie Alien, in which the android Ash attempts to kill Ellen Ripley in the same fashion.
- Alien: Isolation (corpse only)