Smythe was a Seegson employee serving as Head of Synthetic Development aboard Sevastopol Station. When a lone Xenomorph was unleashed on the station by the crew of the Anesidora in 2137, he became one of the survivors desperately waiting for rescue.
Spedding and Smythe were in charge of trying to convince VIPs and clients into buying the Working Joe android model instead of the Weyland-Yutani's variant. If they failed, the jobs Seegson had allocated them on Earth would be cancelled.
Symthe had messed up the android presentation during the tour with the final bidders, failing to receive any buyers. Spedding angrily fired Smythe, calling him a "jackass" in one of his audio logs. Smythe sent him an archive log stating that he was happy that he fired him since he hated working for him.
During the Xenomorph infestation, Smythe and fellow survivor Russel took refuge outside the Synthetic Showroom where they hoarded supplies. Russel announced to any remaining survivors who came across his archive log that he would be setting up a shop inside the Synthetic Showroom.
Whilst Ripley was onboard the station, Russel and Smythe were exploring Seegson Synthetics around the fluid plant reception. The two split up to search for supplies, and shortly afterward Russel encountered a Working Joe. Panicking, Russel ran to the elevator and escaped, abandoning Smythe. Afterwards, he shut down access to the elevator to prevent the Joe from following him. Smythe remained oblivious to this until he too encountered the Joe patrolling the reception. Terrified, he simply hid and silently observed as the Joe stood staring at Russel's old magazines.
Upon returning to his shop, Russel sent a message to Smythe assuring that he will come back for him. After reading the message, Smythe realized that Russel had abandoned him and angrily replied to the message.
Unfortunately for both men, Russel was killed through unknown means before he could reach Smythe. Smythe himself was then attacked and subdued by the Joe. The Joe then proceeded to shove a rolled up magazine down Smythe's throat which he choked to death on, killing him.
- The rolled up magazine forced down Smythe's throat is a direct homage to the original movie Alien, in which the android Ash attempts to kill Ellen Ripley in the same fashion.
- Alien: Isolation (corpse only)