Sheppard was hired by the Weyland Corporation to provide security aboard the USCSS Prometheus during its voyage to the distant moon LV-223. After spending two years in hypersleep, Sheppard along with the other crew members were awaken. As the Prometheus nearly arrives on LV-223, Vickers, Shaw and Holloway briefed the crew on their mission to find the Engineers.
Sheppard along with fellow mercenaries Jackson, Vladimir and Taplow later attempted to kill Fifield who has been mutated by the Black Liquid and was running rampant at their ship's hangar bay by shooting him multiple times with pistols, but the mutated Fifield proves to be too agile, fast and resilient. Sheppard was later killed when Fifield throws him against the side of the RT-01 Transport, just after killing Taplow.