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Prometheus may refer to:
- Prometheus (soundtrack), the soundtrack to the 2012 film.
- Prometheus (novel), the novelization of the film of the same name.
- Prometheus (comics line), a line of comic books based on the Prometheus franchise from Dark Horse Comics.
- Prometheus Tech, the codename for stolen Yautja technology in the video game Predator: Concrete Jungle.
- USCSS Prometheus, a spacecraft in the 2012 film Prometheus.