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Prometheus may refer to:
- Prometheus Tech, the codename for stolen Yautja technology in the video game Predator: Concrete Jungle.
- Prometheus (film), a 2012 film directed by Ridley Scott.
- USCSS Prometheus, a ship manufactured by Weyland Corp.
- Prometheus (soundtrack), the soundtrack to the 2012 film.
- Prometheus (novel), a 2012 novelization of the film of the same name.