The Octo-Facehuggers are found inside the Engineer temple on LV-426 by Holloway, contained within molluscoid, egg-like sacs found inside honeycomb-like recesses on the ceiling of a large chamber. One of the creatures subdues and impregnates Holloway. Jocelyn Watts later finds the chamber where the Octo-Facehuggers are held, although she flees before rousing any of them.
The sacs containing the Octo-Facehuggers open when they detect movements, and the creature within descends onto its prey on a long strand of mucus. They latch onto the victim's face and impregnated them with a Beluga-Xenomorph embryo, before detaching and dying, like a Facehugger. They are capable of secreting acid to melt through any helmet or other obstruction the victim may be wearing, again like a Facehugger.
- The Octo-Facehugger is implied in Spaihts' script to be the 'original' form of the Xenomorph, while the Facehuggers seen in the earlier films (and later in the script) are a 'weaponized' version of it, modified and improved by the Engineers.