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Mother may refer to:
- MU/TH/UR 6000, the computer mainframe installed aboard the USCSS Nostromo.
- MOTHER, a series of two AI mainframes that governed the operation of Neonopolis.
- MU-TH-UR, the computer mainframe installed aboard the USCSS Covenant.
- MU/TH/UR 8500, the computer mainframe installed aboard the UAS Endeavor.