Taplow was hired by Weyland Corp to provide security aboard the USCSS Prometheus during its voyage to the distant moon LV-223. After spending two years in stasis, Taplow along with the other crew members were awakened. When the Prometheus was nearly at LV-223, Vickers, Shaw and Holloway briefed the crew on their mission to find the Engineers.
Taplow along with fellow mercenaries Jackson, Furdik and Sheppard were in the Prometheus' hangar when a mechanic discovered Fifield (whom the crew had lost in the Temple earlier) outside the hangar door. When the mechanic opened the door Fifield (who was infected by the black liquid) killed him and began running rampant inside the hangar. Taplow tried to kill the monster by burning it with a flamethrower, but after setting the creature on fire, it managed to escape by climbing above the RT Series Group Transport. The mutant then jumped on Taplow and smashed his helmet thus killing him.