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- "He was boned like a fish."
- ―Dr. Edwards (from Predator 2)
Being the foremost forensic pathologist in Los Angeles, Dr. Edwards was involved in investigating many of the serious crimes that occurred in the city. Mike Harrigan in particular had a great deal of respect for her, once claiming that her work had solved more crimes than the rest of the LAPD put together.
As a consequence of her position, many of the mutilated bodies left by the City Hunter found their way to her laboratory, including that of Detective Danny Archuleta. Harrigan also went to Irene with the Yautja Spear he recovered from Ramon Vega's apartment. She quickly deduced the material used its construction could cut like steel yet had almost no weight. Upon closer inspection she discovered it was a crystalline substance, similar in structure to diamond but considerably harder and not made of any known element on the periodic table. Her analysis led Harrigan to correctly assume it was part of some form of incredibly advanced technology that Peter Keyes sought to acquire.