- "I'm not going to terminate the alien, Davis. I'm going to harvest it. Alive."
- ―Dr. Hollis (from Aliens: Defiance)
Encounter with Zula and DavisEdit
During a Xenomorph infestation aboard the Wright-Aberra fuel depot, Hollis became the last survivor and had succeeded in sealing off certain areas to aid in her survival. Hollis meets Zula and Davis in the fuel lines and explains the situation to them.
Hollis suggests that the two wait for backup, much to Zula and Davis' confusion. Hollis reveals that a heavily armed squad of Colonial Marines threatens to cut things short. Davis believes that the marines were there to take a Xenomorphic sample back to Earth under Weyland-Yutani's orders. Zula admits to Davis that she has been in contact with Dr. Emi Yang, her physician, back at Luna Tranquillity Base.
The group suddenly trigger a containment event protocol. Zula and Davis become soon become separated from Hollis and Hollis becomes trapped with several Facehuggers. Hollis is able to hold them off before Zula get's the door open and Davis kills the remaining Facehuggers.
The three are able to escape on the Europa, destroy the marine's ship before they take a sample, and blow up the fuel depot. Hollis in her own quarters, appearing very sickly, checks herself in a mirror and later goes to the ship's medical bay to have a sonogram scan of herself.
Back on the Europa, Hollis reveals to Zula and Davis that she is pregnant with a Xenomorph Queen embryo. Hollis says that she wants to surgically remove the embryo so that she can study the specimen, hoping to find a weakness in the alien species. The surgery was a success and Davis hastily throws the Queen Chestburster into a chamber where it is cryogenically freezed. Hollis takes a sample and begins studying it.
Despite appearing okay after the procedure, Hollis becomes infected and is forced to rest in a quarantined bed, her oxygen supply being cut off from the rest of the ship. Zula is seen talking to Hollis before being interrupted by Davis, citing that there is a problem.
It is revealed that the Queen is growing and becoming increasingly restless. As Davis attempt to fix the issue, Zula notices a pirate ship approaching the Europa, with numerous pirates boarding the ship with the intention of obtaining the Queen. Zula and Davis are able to hold off the pirates until Davis becomes seriously wounded. Hollis suggests that they unleash the Queen to use against the pirates. The plan is a success, as Zula releases the Queen from captivity and it slaughters the remaining pirates. Hollis exclaims how the Queen looks barely scratched afterwards. With the ship and her back in critical condition, Zula is left with no other choice but to send coordinates to Earth.
Setting a course for EarthEdit
Zula and Hollis manage to regroup with the wounded Davis as they discuss matters, Zula promises Hollis and Davis immunity to prosecution through Dr Yang, but Davis and Hollis are doubtful of Davis' chances, with Davis believing the company will see him as nothing more than "hardware".
As the Europa approaches Earth's moon, Luna air defense is hostile and begins firing at the Europa after Davis ejects the Queen into space and blows it up, but later ceases after staff back at Luna detect another lifeform aboard the ship and let it go. Zula and Hollis are forced to abandon Davis, who is still in the Europa and eject themselves from the ship in escape pods.