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Specific Expansion Needed: Needs AVP Fire and Stone plot info.
Francis Lane was an astrobiologist who was part of the crew of the Geryon sent on a 'salvage mission' on the moon LV-223. He was responsible for injecting his construct assistant Elden with Chemical A0-3959X.91 – 15, and unintentionally unleashing him onto the salvage team.
Two days before arriving at the moon, passenger Clara Atkinson begins recording a documentary using a PUP-like device. She introduces the camera to Francis Lane and begins talking to him. After the discussion, Francis contacts Elden, stating that if Clara talks to him, to not bring up his "medical condition" (cancer).
Francis and the rest of the crew land on the moon and begin exploring the terrain and are met with a lush jungle, bristling with strange alien life. They later come across a field of deceased mauled creatures and a lake of black goo. Francis becomes intrigued with the liquid and begins examining it, with Elden remaining cautious.
The prime discovery made by the crew however was an old vessel from the colony Hadley's Hope located on the neighboring moon LV-426 — containing a horde of hostile Xenomorphs which they unwittingly unleash.
Separated from the rest of the crew, Francis and Elden take shelter in a remote cave. They uncover the research left behind by the cave's previous inhabitant — a survivor of the Onager crash, Derrick Russel. After reading the survivor's work, Francis deduces that the result of the jungle was due to a crashed alien ship that had released numerous urns of black goo in the process, mutating the environment. Francis determines that the genetic accelerant's mutation process could be filtered to be the long sought cure for his cancer. Francis requests for a reluctant Elden to be the filter, and injects him with a "drop" of the liquid. Elden begins mutating violently and starts chasing Francis.
Francis is able to escape from Elden and coincidentally bumps into Angela Foster and the rest of the crew, who had set off to find the two missing crewmembers, he admits to injecting Elden with the black goo. The crew seizes Francis and Angela has him put under arrest.
Galgo, Piper and Higgins decide to take the Perses and fly back to the Geryon and abandon the rest of the crew. Elden, knowing that Francis is in the Perses, pilots the Helios and takes off to find and kill Francis.
Eventually, Elden reaches the Geryon and demands Galgo to turn over Francis to him. Galgo does so for the sake of the safety of his crew, but the exchange goes awry when the Geryon is boarded by Predators. During the chaos, Francis is separated from Galgo, who fled on the Perses, trying to prolong his life while being hunted by Elden.
Francis finally outwits Elden and takes a sample of his accelerant-latent blood in the hope of curing his cancer. Unfortunately, the accelerant only stimulats Francis's malignancy and turns his entire body into a mass of tumorous growths. Before his body wastes away, Francis makes peace with Elden and urges him to make use of his extended life.
When Lane was first introduced, he was kind, humorous and was shown to have a fascination in his work. Despite these traits, although he is not necessarily an evil person, it's revealed that he is consistently selfish and is capable of using people for his own personal gain, much like Carter Burke.