The Combat Knife is a specialized knife designed for combat purposes. Although a limited combat weapon, the Knife was nonetheless valuable when fighting Yautja, and could be used to cut through the net fired by a Yautja Netgun.
- In Predator, the members of Dutch's team carry assorted combat blades, most notably Dutch himself, who uses his machete to pin a guerrilla to a pole during the assault on the rebel camp, and Billy, who attempts to face the Jungle Hunter armed only with his large combat knife.
- In Aliens: Rogue, Private Choi kills Bergren with a well-thrown combat knife to the chest, before making a futile last stand against a group of Xenomorphs with two knives drawn.
- In Aliens versus Predator 2, the Combat Knife is standard issue equipment for all Colonial Marines. It is mostly only suited to cutting away debris, but is also useful for silent kills against human opponents, against Chestbursters, and can be used to cut through the net fired by a Yautja Netgun.
- In Predators, Royce carries a large machete which he uses to slash off a Hell-Hound's head when the group is first attacked.
- The Combat Knife in Aliens versus Predator 2 seems to be a cross between a military bayonet and survival knife, due to the bayonet ring and serrated edge.