Private Cole was part of Sergeant Lopé's security team aboard the colonization spacecraft USCSS Covenant. He was serving on the ship during its disastrous voyage to Origae-6, during which it suffered several catastrophes that resulted in the loss of most of the ship's crew and its hijacking by David.
When two Neomorphs attacked the team, Cole, Rosenthal and Ankor helped fight the first Neomorph, though they only angered it and, though Ankor was killed, Cole managed to avoid a similar fate. After the first Neomorph was killed, a synthetic named David showed up and fired a flare gun into the air, scaring the second one off. David then ordered the team to follow him to his safe haven. With no way to contact the Covenant and a storm preventing the Covenant from getting to them anyway, they had no choice but to follow him.
After arriving at David's temple, Cole helped re-establish communications with the Covenant. After requesting extraction, they were told they had to wait until morning to be rescued due to the storm.
Later that night, Rosenthal went missing. The team's captain Chris Oram elected to find her, only to never return. Cole and Lopé went looking for the two, and eventually Cole found Rosenthal's mutilated corpse along with a dead Neomorph which had been killed by Oram. Searching further through the temple, Cole found Oram, who was dead with his chest horrifically ripped open by a Chestburster.
As he looked around, he was ambushed by a Facehugger, which latched itself on to his gun. Cole threw it off and tried to shoot it, though it dodged his gunfire and instead ran toward Lopé. As the two tried to locate it, it attacked Lopé and latched on to his face. As Lopé struggled to pull the Facehugger off, Cole ran over to him and using his knife he cut it off and threw it aside, saving Lopé - though the resultant acid spray still burnt Lopé's left cheek and left him screaming in agony.
As Cole tried to bandage Lopé's wound, the Xenomorph born from Oram appeared from an overhead shaft. Shocked, Lopé immediately got up and ran off as it immediately dropped down and landed on Cole, before swiftly killing him with a headbite and tearing his corpse apart.