One of the most well-respected painters in the field, Eggleton has illustrated numerous novel, book and comic book covers, trading cards and other projects. He has been honored with the Hugo Award for Best Professional Artist eight times, first winning in 1994. He also won the Hugo Award for Best Related Book in 2001 for his art book Greetings From Earth. He has also won the Chesley Award for Artistic Achievement in 1999 and was the guest of honor at Chicon 2000. In addition to his numerous book covers, Eggleton has notably worked on the Magic: The Gathering cards series and with the character Godzilla in various forms.
Asteroid 13562 was named Bobeggleton in his honor.